Publications

Key Published Literature

Benz MS, Packo KH, Gonzalez V, et al. A placebo-controlled trial of microplasmin intravitreous injection to facilitate posterior vitreous detachment before vitrectomy. Ophthalmology. 2010;117(4):791-797. http://www.ncbi.nlm.nih.gov/pubmed/20138368

de Smet MD, Gandorfer A, Stalmans P, et al. Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trial. Ophthalmology. 2009;116(7):1349-1355. http://www.ncbi.nlm.nih.gov/pubmed/19447497

de Smet MD, Valmaggia C, Zarranz-Ventura J, Willekens B. Microplasmin: ex vivo characterization of its activity in porcine vitreous. Invest Ophthalmol Vis Sci. 2009;50(2):814-819. http://www.ncbi.nlm.nih.gov/pubmed/18806295

Gad Elkareem AM, Willekens B, Stassen JM, de Smet MD. Differential vitreous dye diffusion following microplasmin or plasmin pre-treatment. Curr Eye Res. 2010;35(3):235-41.

Gad Elkareem AM, Willekens B, Vanhove M, Noppen B, Stassen JM, de Smet MD. Characterization of a stabilized form of microplasmin for the induction of posterior vitreous detachment. Curr Eye Res. 2010;35(10):909-915. http://www.ncbi.nlm.nih.gov/pubmed/20858112

Gandorfer A, Rohleder M, Sethi C, et al. Posterior vitreous detachment induced by microplasmin. Invest Ophthalmol Vis Sci. 2004;45(2):641-647. http://www.ncbi.nlm.nih.gov/pubmed/14744909

Gandorfer A. Enzymatic vitreous disruption. Eye (Lond). 2008;22(10):1273-1277. http://www.ncbi.nlm.nih.gov/pubmed/18292784

Gandorfer A. Experimental evaluation of microplasmin – an alternative to vital dyes. Dev Ophthalmol. 2008;42:153-159. http://www.ncbi.nlm.nih.gov/pubmed/18535388

Gandorfer A. Microplasmin-assisted vitrectomy. Dev Ophthalmol. 2009;44:26-30. http://www.ncbi.nlm.nih.gov/pubmed/19494649

Gandorfer A. Pharmacological vitreolysis [in German]. Klin Monbl Augenheilkd. 2011;228(3):201-207. http://www.ncbi.nlm.nih.gov/pubmed/20845257

Giblin FJ, Quiram PA, Leverenz VR, Baker RM, Dang L, Trese MT. Enzyme-induced posterior vitreous detachment in the rat produces increased lens nuclear pO2 levels. Exp Eye Res. 2009;88(2):286-292. http://www.ncbi.nlm.nih.gov/pubmed/18835558

Goldenberg DT, Giblin FJ, Cheng M, et al. Posterior vitreous detachment with microplasmin alters the retinal penetration of intravitreal bevacizumab (Avastin) in rabbit eyes. Retina. 2011;31(2):393-400. http://www.ncbi.nlm.nih.gov/pubmed/21099453

Goldenberg DT, Trese MT. Pharmacologic vitreodynamics and molecular flux. Dev Ophthalmol. 2009;44:31-36. http://www.ncbi.nlm.nih.gov/pubmed/19494650

Lopez-Lopez F, Rodriguez-Blanco M, Gómez-Ulla F, Marticorena J. Enzymatic vitreolysis. Curr Diabetes Rev. 2009;5(1):57-62. http://www.ncbi.nlm.nih.gov/pubmed/19199900

Quiram PA, Leverenz VR, Baker RM, Dang L, Giblin FJ, Trese MT. Microplasmin-induced posterior vitreous detachment affects vitreous oxygen levels. Retina. 2007;27(8):1090-1096. http://www.ncbi.nlm.nih.gov/pubmed/18040251

Sakuma T, Tanaka M, Mizota A, Inoue J, Pakola S. Safety of in vivo pharmacologic vitreolysis with recombinant microplasmin in rabbit eyes. Invest OphthalmolVis Sci. 2005;46(9):3295-3299. http://www.ncbi.nlm.nih.gov/pubmed/16123432

Sebag J, Ansari RR, Suh KI. Pharmacologic vitreolysis with microplasmin increases vitreous diffusion coefficients. Graefes Arch Clin Exp Ophthalmol. 2007;245(4):576-580. http://www.ncbi.nlm.nih.gov/pubmed/16941141

Sebag J. Molecular biology of pharmacologic vitreolysis. Trans Am Ophthalmol Soc. 2005;103:473-94.473-494. http://www.ncbi.nlm.nih.gov/pubmed/17057814

Stalmans P, Delaey C, de Smet MD, van Dijkman E, Pakola S. Intravitreal injection of microplasmin for treatment of vitreomacular adhesion: results of a prospective, randomized, sham-controlled phase II trial (the MIVI-IIT trial). Retina. 2010;30(7):1122-1127. http://www.ncbi.nlm.nih.gov/pubmed/20616687

Udaondo P, Diaz-Llopis M, Garcia-Delpech S, Salom D, Arevalo JF. Microplasmin for vitreomacular traction. Ophthalmology. 2010;117(9):1859; author reply 1859-1860. http://www.ncbi.nlm.nih.gov/pubmed/20816250